Aphasia After Therapy


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How speech and language therapy can help

Warning You have reached the maximum number of saved studies Transcranial Magnetic Stimulation and Constraint Induced Language Therapy for Chronic Aphasia The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.

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Listing a study does not mean it has been evaluated by the U. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. Last Update Posted : April 5, See Contacts and Locations.

Constraint-induced therapy of chronic aphasia after stroke.

Study Description. Transcranial Magnetic Stimulation TMS has been demonstrated to improve language function in subjects with chronic aphasia in a number of small studies, many of which did not include a control group.

Aphasia: Remembering your Words

Although the treatment appears promising, data to date do not permit an adequate assessment of the utility of the technique. Change from baseline in the Western Aphasia Battery Aphasia Quotient at 6 months after the end of TMS treatment will serve as the primary outcome measure. A secondary aim is to identify anatomic and behavioral predictors of response to treatment. Finally, a third aim is to identify the mechanism underlying the beneficial effect of the treatment using a variety of imaging techniques. Using modern network analyses and robust machine learning techniques, the investigators will identify changes in the strengths of connections between nodes in the language network to address specific hypotheses regarding the effects of TMS and CILT on brain organization that are associated with beneficial response to treatment.

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Each TMS treatment session will be immediately followed by a minute session of CILT There will be two 3-month post-treatment visits and two 6-month post-treatment visits in which the full battery of language and cognitive assessments will be repeated. FDA Resources. Arms and Interventions. There will be 10 TMS sessions over 2 consecutive weeks in which 20 minutes pulses of 1 Hz sham TMS will be delivered to the inferior pars triangular. Outcome Measures. Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision.

Suffered their stroke at least 6 months prior to their testing Must be able to understand the nature of the study, and give informed consent Exclusion Criteria: Multiple strokes excluding small lacunar strokes as defined by brain imaging History of substance abuse Previous head trauma with loss of consciousness for more than 5 minutes Psychiatric illness We note that subjects will be assessed with the item Geriatric Depression scale.

Because depression is very difficult to evaluate in aphasic subjects, potential subjects will not be excluded on the basis of the depression score Chronic exposure to medications that might be expected to have lasting consequences for the central nervous system e. Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials. Layout table for investigator information Principal Investigator: H. More Information. J Speech Hear Disord. Howard, D. Thames Valley Test Company. Retrieved from books. Ruff, R. Ruff figural fluency test: professional manual. Psychological Assessment Resources. A system for quantifying the informativeness and efficiency of the connected speech of adults with aphasia.

J Speech Hear Res. Constraint-induced therapy of chronic aphasia after stroke.

JMIR Publications

A pilot study of use-dependent learning in the context of Constraint Induced Language Therapy. J Int Neuropsychol Soc. Barthel, G. Intensive language therapy in chronic aphasia: Which aspects contribute most? Aphasiology, 22 4 , Goral M, Kempler D. First decade of research on constrained-induced treatment approaches for aphasia rehabilitation. Arch Phys Med Rehabil. Effectiveness of low-frequency rTMS and intensive speech therapy in poststroke patients with aphasia: a pilot study based on evaluation by fMRI in relation to type of aphasia.

Eur Neurol.

Epub Aug Low-frequency rTMS promotes use-dependent motor plasticity in chronic stroke: a randomized trial. Epub Jan Long term language recovery subsequent to low frequency rTMS in chronic non-fluent aphasia. Improved receptive and expressive language abilities in nonfluent aphasic stroke patients after application of rTMS: an open protocol case series.

Brain Stimul. Epub Apr Stimulating conversation: enhancement of elicited propositional speech in a patient with chronic non-fluent aphasia following transcranial magnetic stimulation. Brain Lang. Epub Feb Erratum in: Brain Lang. Effects of low-frequency repetitive transcranial magnetic stimulation combined with intensive speech therapy on cerebral blood flow in post-stroke aphasia.

Transl Stroke Res. Epub Aug 7. Therapeutic application of 6-Hz-primed low-frequency rTMS combined with intensive speech therapy for post-stroke aphasia. Brain Inj. Epub Sep 8. A multi-center study on low-frequency rTMS combined with intensive occupational therapy for upper limb hemiparesis in post-stroke patients. J Neuroeng Rehabil.


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However, most people undergo speech and language therapy to rehabilitate their language skills and supplement their communication experiences. Researchers are currently investigating the use of medications, alone or in combination with speech therapy, to help people with aphasia. Recovery of language skills is usually a relatively slow process.

Although most people make significant progress, few people regain full pre-injury communication levels.


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For aphasia, speech and language therapy tries to improve the person's ability to communicate by restoring as much language as possible, teaching how to compensate for lost language skills and finding other methods of communicating. Certain drugs are currently being studied for the treatment of aphasia. These include drugs that may improve blood flow to the brain, enhance the brain's recovery ability or help replace depleted chemicals in the brain neurotransmitters. Several medications, such as memantine Namenda and piracetam, have shown promise in small studies.

But more research is needed before these treatments can be recommended. Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this disease. Family members and friends can use the following tips when communicating with a person with aphasia:. Local chapters of such organizations as the National Aphasia Association, the American Stroke Association, the American Heart Association and some medical centers may offer support groups for people with aphasia and others affected by the disorder.

These groups provide people with a sense of community, a place to air frustrations and learn coping strategies. Ask your doctor or speech-language pathologist if he or she knows of any local support groups. If your aphasia is due to a stroke or head injury, you'll probably first see an emergency room physician.

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You'll then see a doctor who specializes in disorders of the nervous system neurologist , and you may eventually be referred to a speech-language pathologist for rehabilitation. Because this condition generally arises as an emergency, you won't have time to prepare. If possible, bring the medications or supplements you take with you to the hospital so that your doctor is aware of them. When you have follow-up appointments, you'll likely need a companion to drive you to your doctor's office. In addition, this person may be able to help you communicate with your doctor. Your doctor will likely have questions, too.

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